Summary of literature regarding transgenic mice with disruptions in vesicular nucleotide transporters (VNTs) in different models of seizures and epilepsy, as well as the known alterations and reorganizations in the expression levels of these VNTs in rodent models for temporal lobe epilepsy (TLE) and in human tissue resected for epilepsy surgery. The gene discussed is SLC17A9; the disease is temporal lobe epilepsy.