Conversely, the copy number gain intersection included quite a number of genes whose overexpression has previously been associated with cancer, such as BIRC5, CCND2, CDK6, HEY1, HGF, HSF1, KIT, MDM2, MET, NTRK3, PDGFR, SNAI2, TK1, and TWIST1. This evidence concerns the gene HGF and cancer.