Conversely, the copy number gain intersection included quite a number of genes whose overexpression has previously been associated with cancer, such as BIRC5, CCND2, CDK6, HEY1, HGF, HSF1, KIT, MDM2, MET, NTRK3, PDGFR, SNAI2, TK1, and TWIST1. Here, TWIST1 is linked to cancer.