Genes that are regulated by parental imprinting frequently have important roles in cell proliferation and tissue growth, so it is interesting that the VTRNA2-1 gene may have a suppressor role in human acute myeloid leukemias and other cancers [8], [18], and that vault RNAs are strongly upregulated during ES cell differentiation [19]. The gene discussed is VTRNA2-1; the disease is cancer.