Claudin-1 expression was shown to be regulated through the modulation of mRNA stability in colon cancer cells [78], and further analysis by the same group showed that histone deacetylase (HDAC)-dependent regulation of claudin-1 mRNA stability is mediated by the binding of Hu antigen R and Tristetraprolin to the 3′ UTR of claudin-1 mRNA [79]. The gene discussed is CLDN1; the disease is colonic neoplasm.