More recent studies confirmed that TGF-β can increase the number of CSC/TICs in breast cancer cell lines [121] and showed that EMT-inducing transcription factors in cooperation with active RAS are sufficient to drive the transformation of human mammalian epithelial cells into malignant cells with the features of claudin-low tumors in transgenic mice [122]. This evidence concerns the gene TGFB1 and breast carcinoma.