Gelsolin can reduce the amyloid burden by acting as an inhibitor of Aβ fibrillization and as an antioxidant and antiapoptotic protein.72, 73 However, the expression level of GSN in the brain of AD patients has been discussed controversially.74, 75 Our data indicate that GSN is significantly downregulated in the AD Cb, which is consistent with a recent report that a reduced plasma GSN level in AD patients was found. Here, GSN is linked to Alzheimer disease.