However, it must be noted that several studies indicated that in AD the cerebellum (Cb) also shows some signs of morphological and metabolic dysfunctions.16 A number of pathological changes, such as widespread deposits of diffuse amyloid, ubiquitin-immunoreactive dystrophic neurites and increased microglia, have been revealed in the AD-affected Cb by immunocytochemical studies. The gene discussed is UBC; the disease is Alzheimer disease.