Recent findings have disclosed the crucial role of AHNAK in myelination processes during development, neuronal plasticity and neuro-re-/de-generation events;67, 68 because the development of tau lesions in AD is traceable to differences between early- versus late-maturing oligodendrocytes and to the exceptionally protracted myelination of late-developing portions of the human brain,69, 70, 71 AHNAK becomes of pivotal interest for future investigations. The gene discussed is MAPT; the disease is Alzheimer disease.