However, several reports have confirmed that the Cb also reveals molecular changes in response to AD, but this area of the brain likely counteracts those changes more efficiently.17, 18, 19, 20, 21, 22, 23, 24 Therefore, we aimed to compare the Cb proteome with the Hp and pCx proteomes to provide critical information on brain region-specific mechanisms that are counteracting the development and progression of aging and AD-related neurodegeneration and may illuminate how the Cb sequesters itself from neuronal death in AD. This evidence concerns the gene HP and Alzheimer disease.