CLU and Alzheimer disease: It is noteworthy that Clusterin (CLU) was downregulated in the Hp, AHNAK was upregulated in the Hp and downregulated in the Cb, the extracellular matrix protein Tenascin-R (TNR) was downregulated in the Hp, HIST1H1D/E were upregulated in the pCx and the Hp and downregulated in the Cb and MECP2 was upregulated in the Hp of AD brains.