RIPK1 and ovarian neoplasm: The N-terminal ovarian tumor (OTU) domain of A20 can deubiquitinate K63 polyubiquitination of RIP1, and the C-terminal zinc-finger (ZnF) region subsequently acts as an E3 ligase to add the K48 polyubiquitin chain to RIP1, thereby promoting its proteasomal degradation18.