Induction of NF-κB and Akt signaling pathways by TNFα secretion inhibits GSK-3β-mediated phosphorylation of Snail and β-catenin, inducing their stabilization and nuclear localization.103, 104 Snail can interact with β-catenin and establish a positive feedback loop for Wnt-dependent transcription.105 Taken together, all the above signaling events contribute to angiogenic activity, accelerated EMT and tumor cell invasion and metastasis. Here, TNF is linked to neoplasm.