CD4 and HIV-1 infection: NVP has been assigned to Pregnancy Category B by the FDA and one of its most relevant benefits is its efficacy in the prevention of mother-to-child transmission of the HIV-1 infection, with the drug being commonly prescribed to pregnant women and their children [35] Nevertheless, NVP is contraindicated in pregnant women with ≥250 CD4 cells/μL due to potential hepatic and cutaneous toxicity [36].