HMGB1 and granulomatosis with polyangiitis: Although not significant, HMGB1 levels were higher in GPA patients with localized disease in comparison with those presenting generalized disease (3.14 (1.87 to 3.78) ng/ml vs. 1.84 (1.30 to 3.36) ng/ml; P = 0.240) as well as in AAV patients with pulmonary nodules and/or infiltrates compared with those presenting alveolar hemorrhage (3.60 ± 1.99 ng/ml vs. 2.09 ± 1.18 ng/ml; P = 0.107), but these differences did not reach statistical significance.