MECP2 and neurofibromatosis: There is dysregulated splicing in some single gene disorders responsible for some forms of syndromic autism (tuberous sclerosis and neurofibromatosis); and still other genes associated with syndromic autisms encode proteins that can modulate alternative splicing (FMR1, MECP2, and SNRPN-Fragile X and Retts Syndrome) [82].