Primary site recurrence (PSR) was significantly associated with high-ITGA3/CD9, tumor size, T3-4 and positive margin, while distant metastasis was associated with high-ITGA3/CD9, a high ITGB4/JUP ratio (high-ITGB4/JUP), and YK4. The gene discussed is ITGB4; the disease is neoplasm.