Aspirin (1–10 mM) and other conventional NSAIDs (e.g., diclofenac (50–200 μM), indomethacin (50–100 μM) and the active sulfide form of sulindac, sulindac sulfide (5–50 μM)) upregulate NAG-1 in the CRC cell line, HCT-116 [26]. This evidence concerns the gene GDF15 and colorectal carcinoma.