Sulindac sulfide (50 μM) inhibits HCT-116 cell invasion by suppressing the NF-κB-mediated transcription of specific microRNAs (e.g., miR-9, miR-17, miR-21) that modulate the expression of genes involved in tumor cell invasion and metastasis [33]. The gene discussed is NFKB1; the disease is neoplasm.