PPARD and neoplasm: In contrast, in response to Wnt signals, degradation of β-catenin is decreased, and cytoplasmic β-catenin accumulates and is translocated to the nucleus, where it associates with T-cell factor (TCF) and lymphoid enhancer factor (LEF) family members to stimulate the expression of tumor-promoting genes (e.g., c-myc, c-jun, cyclin D1, matrilysin, peroxisome proliferator-activated receptor delta (PPARδ)) [35].