Our data show that FMR6 expression is significantly downregulated in FXS brain samples, as is expected due to the reported decrease in H4Ac and H3K4me2 and increase in H3K9me2 throughout the FMR1 locus, including the 3′ region of FMR1 (Gheldof et al. 2006). The gene discussed is FMR1; the disease is fragile X syndrome.