LPL and Alzheimer disease: In contrast to these findings, LPL immunoreactivity was noticeably absent from intraneuronal tangles, although another study previously reported significant association between LPL polymorphism and neurofibrillary tangle density in AD human brain (Blain et al. 2006); this suggests the possibility that LPL function in the brain indirectly affects formation of neurofibrillary tangles in AD.