LPL and brain disorder: LPL-facilitated uptake of lipoproteins is potentially of high importance in the brain, because lipoprotein uptake by neuronal cells is relevant for structural and functional integrity of synapses (Mauch et al. 2001; Göritz et al. 2005; Fester et al. 2009), and changes in lipoprotein metabolism have been shown to play a role in the pathogenesis of different brain diseases (Danik et al. 1999; Hayashi, 2011).