No relation could be established between recurrent anaphylaxis and the patient’s sex (P = 0.70), underlying atopy (P = 0.15) or asthma (P = 1.0), life-time number of Hymenoptera stings (P = 0.46), the decline of skin test reactivity (P = 0.45) or specific IgE (P = 0.12) during VIT, the time interval from index sting to initiation of VIT (P = 0.67), and the duration of VIT (P = 0.56). Here, IGHE is linked to anaphylaxis.