AFP and chronic hepatitis B virus infection: The present results indicated that decreasing serum total bilirubin, INR and MELD score and increasing serum AFP at week 2 were good indicators for survival in SAE of chronic hepatitis B. In the meanwhile, it was noted that an increase in serum total bilirubin (baseline to week-2) in the patients combined with baseline bilirubin >10 mg/dl had the PPV of 80% for mortality, while the NPV was 100% for decreasing serum total bilirubin in the 2-week period.