With regards to the potential clinical relevance of this specific ncRNA family in cancer, recent reports indicated the association of SNORD25, SNORD27, SNORD30, and SNORD31 with progression from smoldering to symptomatic MM [18] and the over-expression of SNORD71 in peripheral T-cell Lymphoma with favorable outcome [22]. Here, SNORD27 is linked to peripheral T-cell lymphoma, not otherwise specified.