Ectopic expression of mutant p53s (R273H, R175H and C135Y) through stable transfection into the p53 knocked-down HEC-50 cell line, a cell line derived from endometrial cancer, showed that these mutants repressed the expression of miR-130b and triggered ZEB1-dependent epithelial–mesenchymal transition and cancer cell invasion [42]. The gene discussed is TP53; the disease is cancer.