This is consistent with other studies reporting dysfunctional TAA‐specific CD8+ T cells.8 It is also a particularly important observation given that the induction of TAA‐specific IFN‐γ production by T cells has been proposed as a major determinant of success in therapeutic tumor vaccine trials targeting other malignancies.2 Furthermore, we found a limited expression of cytotoxic mediators by the expanded TAA‐specific CD8+ T cells. This evidence concerns the gene CD8A and neoplasm.