CD8A and neoplasm: First, the immunosuppressive tumor microenvironment may be responsible, for example, by the production of immunoregulatory cytokines or by the local action of inhibitory receptors such as PD‐1, as described recently in a mouse model.22 This is in line with our observation of significantly reduced magnitudes of TAA‐specific CD8+ T‐cell responses at the tumor site compared to the periphery.