FBXW7 is an F-box protein that provides substrate recognition to the CUL1-SKP1-RBX1 SCF ubiquitin ligase (SCFFBXW7) complex [Bai et al., 1996; Feldman et al., 1997; Skowyra et al., 1997; Skowyra et al., 1999] and has previously been reported to be somatically mutated in human cancers and to be disrupted by a RCC-associated constitutional translocation [Davis and Tomlinson 2012; Kuiper et al., 2009; Tan et al., 2008; Welcker and Clurman 2008]. The gene discussed is CUL1; the disease is renal cell carcinoma.