As HIF dysregulation plays a key role in VHL-associated renal tumorigenesis, we investigated expression of the HIF-1 and HIF-2 targets [carbonic anhydrase 9 (CA9) and cyclin D1 (CCND1), respectively] in three t(5;19)(p15.3;q12) associated renal tumors from individuals III:1 and III:2 (two oncocytomas and one chromophobe RCC). This evidence concerns the gene HIF1A and oncocytic adenoma.