VHL and renal cell carcinoma: Familial RCC is genetically heterogeneous and many patients do not have mutations in known inherited RCC genes [e.g., VHL, FH (MIM #136850, #150800), FLCN (MIM #607273, #135150), MET (MIM #164860, #605074), SDHB (MIM #185470, #115310, #171300) [Maher, 2011; Ricketts et al., 2008; Woodward et al., 2008].