Although components of E3 ubiquitin complexes (e.g., VHL and FBXW7) have been clearly implicated in tumorigenesis [Bernassola et al., 2008; Sun, 2003; Sun 2006], there is relatively little information regarding the potential role of E2 conjugating enzymes, though increased expression of some (e.g., UbcH10 and E2-EPF) has been described in some cancers [Okamoto et al., 2003; Roos et al., 2011; Seghatoleslam et al., 2012; Tedesco et al., 2007]. This evidence concerns the gene VHL and cancer.