VHL and neoplasm: Interestingly, although the mechanism of tumor suppression of several inherited RCC genes (e.g., VHL, FH, FLCN, and SDHB) has been linked to HIF-1/HIF-2 related pathways, we did not identify evidence of HIF target dysregulation in t(5;19)(p15.3;q12) associated renal tumors (and there was no relationship between UBE2QL1 status and the presence or absence of a VHL mutation in sporadic RCC).