UBE2QL1 and renal cell carcinoma: Our findings illustrate how analysis of rare inherited forms of RCC can provide candidate TSGs that would not be detected by exome resequencing studies (as somatic inactivation of UBE2QL1 occurred through epigenetic silencing and deletions) and note that the absence of frequent intragenic UBE2QL1 mutations is reminiscent of RASSF1A which is often inactivated by methylation/allele loss in sporadic RCC [Dreijerink et al., 2001; Morrissey et al., 2001; Richter et al., 2009].