Nonsense and frame shift mutations in RBM10 have been identified to be causative for TARP syndrome (Talipes equinovarus, atrial septal defect, Robin sequence and persistent left superior vena cava, MIM #311900), an X-linked inherited disorder leading to multiple organ malformation in affected males (Gripp et al, 2011; Johnston et al, 2010). Here, RBM10 is linked to TARP syndrome.