IL4R and neoplasm: This acquired microglia deactivation has been studied thoroughly in tumour models in which the tumours are a source of anti-inflammatory cytokines (IL4, IL6, IL10 and TGFβ) [47] that induce microglia deactivation through signalling via their receptors (IL4R, IL6R, IL10R and TGFβR), leading to the suppression of immune responses against the tumour [48].