In the present study C to T substitution at position 936 within the 3′-untranslated region of the VEGF gene and C to G substitution at position −921 within the promoter region of the bFGF gene were analysed in order to determine whether the presence of these allelic variants is associated with susceptibility and progression of the disease in NHL patients. This evidence concerns the gene FGF2 and non-Hodgkin lymphoma.