CASP3 and ischemia: However, the coadministration of zinc and L-NAME (two inhibitors of NO production) showed a cytotoxic effect during a cerebral hypoxia ischemia in the rat, increasing the lipoperoxidation and cleaved caspase-3 IR cells from the early phase of a hypoxia-ischemia process, through the zinc accumulation in the early phase and an increase of zinc and the NO production in the late phase.