TIMP1 and Cirrhosis: On the other hand, administration of BR extract to the animals significantly (P < 0.05) attenuated the enzymatic levels of MMP-2, MMP-9, and TIMP-1 to approach the values of the reference control group with the exception of the low dose BR-treated group which did not show significance to cirrhosis group indicating the efficacy of the plant extract treatment in a dose-dependent manner.