In the current study, we observed significant increase in the serum level of Bax protein and caspase-3 and decrease in Bcl-2 protein in the BR-treated and silymarin-treated animals compared to cirrhosis group animals as shown in the relation between Bax, Bcl-2, and caspase-3 in Figure 3(d). This evidence concerns the gene CASP3 and Cirrhosis.