NR1H4 and cholestasis: Although nuclear receptors other than PPARα are suggested to be potential targets in cholestasis like FXR and PXR [43], there is interplay between different nuclear receptors; for example, there is crosstalk between the PPARα and FXR transcriptional pathways because PPARα is an FXR target gene harboring an FXR response element in its gene promoter [4].