In rats with endothelin (ET)-1 induced transient middle cerebral artery occlusion (tMCAO), I.C.V infusion of Ang-(1-7) or diminazine aceturate, an ACE2 activator, could significantly attenuate the cerebral infarct size and neurological deficits after the ischemia insult [9]. The gene discussed is EDN1; the disease is ischemia.