HSPA1A and brain ischemia: When transgenic mice heterozygous for a porcine HSP70i gene ([+]HSP72), transgene-negative littermate controls ([–]HSP72), and normal Institute of Cancer Research-strain mice were subjected to heat stress (40°C) [97], HSP72 overexpression in multiple organs of the [+]HSP72 mice improved heatstroke survival by reducing cerebral ischemia and damage.