Septic shock, a systemic inflammatory syndrome, is caused primarily by Gram-negative bacteria, which erupt when endotoxin or other microbial products initially produce tumor necrosis factor-α (TNF-α), IL-1, IL-6, interferon-γ, leukemia inhibitory factors, migration inhibitory factor, platelet activating factors, and products of the complement and clotting cascades [30]. This evidence concerns the gene TNF and septic shock.