The overexpression of CXCL10 or interferon gamma-induced protein 10 (IP-10) has been observed in several neurodegenerative diseases including multiple sclerosis (MS), Parkinson's disease (PD) HIV-associated dementia, and Alzheimer's disease (AD) [28–31]. Here, CXCL10 is linked to early-onset autosomal dominant Alzheimer disease.