The benign prostate epithelial RWPE-1 cell line, the benign prostatic hyperplasia-derived cell line BPH-1, as well as DU145 and PC-3 cell lines showed low or undetectable levels for AR and low levels of GNMT. It was therefore clear that the expression of GNMT was limited to prostate lines expressing high levels of AR. The gene discussed is AR; the disease is benign prostatic hyperplasia.