In a study on Head and Neck Squamous Cell Carcinomas (HNSCC), N. Brockton and colleagues reported that a high stromal CA IX expression was associated with significantly reduced overall survival in patients with HPV-negative cancers, suggesting that CA IX expression in these tumors could identify patients with poor prognosis and inform therapeutic strategies [113]. The gene discussed is CA9; the disease is head and neck squamous cell carcinoma.