Tumours overexpressing cytoplasmic NHERF1 (49.6%) showed a significant association with pT3-pT4 depth of invasion, high nodal status, the presence of distant metastases (P = 0.000 for all, data not shown), higher TNM stage (P = 0.000), poor differentiation grade (P = 0.000) and the presence of LVI (P = 0.000). The gene discussed is NHERF1; the disease is neoplasm.