Although repeated observational data described an independent association between PTH levels and unfavorable outcomes in CKD stage 3–5 [1–3] as well as in ESRD patients [4, 5], no randomized controlled trials (RCTs) have still proven that an active reduction of PTH values could improve patient-centered outcomes as hospitalizations, cardiovascular events (CVE), CKD progression, and survival. Here, PTH is linked to chronic kidney disease.