The deregulation of signaling pathways including MAPKs, p53, Sex steroid, Wnt/β-catenin, transforming growth factor β (TGFβ), PI3K/AKT, cytokines, IKK/NF-κB and Hedgehog (Hh) were found to be closely related with HCC development. The gene discussed is TP53; the disease is hepatocellular carcinoma.