KLK3 and pachyonychia congenita: As shown in Figure 2(c), the loss of RKIP expression was associated with significantly increased positivity for NF-κB p50 subunit (25% and 44.4%, P < 0.05) in PC patients with (PSA+, PSMA+) profile, while there was no significant difference in the positivity for NF-κB p65 subunit (25% and 22.2%).