On the basis of the above results, it seems that according to RKIP, our PC patients with (PSA+, PSMA+) profile could exhibit the feature of two different PC phenotypes: an androgen-dependent phenotype for PC patients keeping the RKIP and an androgen-independent phenotype for those missing the RKIP (Figure 3). This evidence concerns the gene PEBP1 and pachyonychia congenita.