Previous studies have shown that in a model of Histoplasma capsulatum infection, another important pathogenic dimorphic fungus, reductions in leukotriene synthesis caused by MK 886 administration, a 5-LO pathway inhibitor [35], or in 5-LO-deficient mice [36], resulted in significant mortality in mice and increased lung CFU at 7 and 14 days post infection. Here, ALOX5 is linked to infection.