TFRC and head and neck squamous cell carcinoma: Additional evidence of the relevance of these iron regulating genes are provided by examination of publicly-available HNSCC databases (www.oncomine.org) [20], confirming significant overexpression of both HFE [21], and TFR1 [21–23] in HNSCC patient samples, demonstrating that this is indeed a commonly dysregulated pathway in this disease.