Early studies show that PP242 treatment inhibits the AKT phosphorylation at S473 (AKTS473), the mTORC2 phosphorylation site on AKT, in colorectal carcinoma cells at 12 hour [48] and pancreatic carcinoma cells at 2 hour of the treatment [34]. Here, AKT1 is linked to exocrine pancreatic carcinoma.