GJB1 and neuromyelitis optica: In actively demyelinating lesions, none of 35 lesions was classified as pattern A. In contrast, 13 of 41 (31.7%) chronic active lesions showed pattern A and five of 13 (38.4%) chronic inactive lesions were classed as pattern A. Five NMO cases (NMO-3, 5, 6, 7 and 10) showed loss of Cx32 and Cx47 beyond the demyelinated areas in at least one chronic active or chronic inactive lesion (pattern A) (Figure 2).