It is intriguing to note that RNAi-mediated depletion of eIF4E2 in U87MG glioblastoma cells in normal conditions [57] has no significant effect on total protein synthesis, while in HeLa cells, an activation of approx. 30% in translation rates was reported [19], indicating a general negative role in translation. This evidence concerns the gene EIF4E2 and glioblastoma.