Compared to the CC genotype, the combined CT and TT genotypes of TNFA-rs1799724 were associated with a 2.3-fold increased breast cancer risk (OR=2.31, 95% CI, 1.35-3.95), whereas carriers of the CRP-rs1205 T allele (CT and TT) had a 46% reduced risk (OR=0.54, 95% CI, 0.33-0.87). The gene discussed is CRP; the disease is breast cancer.