A recent Meta-Analysis reported a small decreased risk of breast cancer (OR=0.91, 95% CI, 0.85-0.97) associated with the TNFA- rs1800629 variant in Caucasians, although this appeared to be largely driven by results from one study (OR=0.55); no associations were observed with TNFA-rs1799964, rs1800630, or rs361525 [48]. This evidence concerns the gene TNF and breast cancer.