Among EAs, carriers of the variant TNFA-rs1799724 T allele were 2-fold more likely to be diagnosed with ER positive breast cancer compared to women who were homozygous for the common allele (OR=2.0, 95% CI, 1.31-3.05, P=0.001), with the association remained significant after correction for multiple testing (P=0.04). The gene discussed is TNF; the disease is breast carcinoma.