Before stratification by menopausal or ER status, there were virtually no significant associations between any SNP examined and overall breast cancer risk in AAs or EAs except that among EA women, carriers of the TNFA-rs1799724 T allele (CT+TT) showed increased breast cancer risk (OR=1.70, 95% CI, 1.17-2.46, P =0.005). This evidence concerns the gene TNF and breast cancer.