In our study, several CCL2 SNPs (rs1024611, rs13900, rs4586) in LD were suggested to be associated with increased risk of premenopausal breast cancer in AA women, although an elevated risk observed for rs4586 in EA women in the initial analysis was attenuated towards the null in our second stage analysis using a larger study population. The gene discussed is CCL2; the disease is breast carcinoma.