OPN1SW and acute lymphoblastic leukemia: SNPs showing the strongest evidence of association based on p-value within each of the three regions included rs7747023 (OR=0.73, 95% CI=0.60-0.89, p=1.7x10-3) of region A, rs3130785 (OR=1.45, 95% CI=1.16-1.82, p=1.3x10-3) of region B, and rs9296068 (OR=1.37, 95% CI=1.17-1.61, p=1.2x10-4) of region C. Multivariable analyses evaluating the independence of associations between the 20 SNPs on BCP-ALL risk (Table S1) resulted in 6 SNPs that maintained low p-values and minimally attenuated risk estimates (Table 2).