Similarly, HLA-B results were not validated in eight ALS patients, found to have deletions according to PennCNV, however, heterozygous deletions were found in other controls and ALS patients who were shown to have two copies by PennCNV (Figure S3b).As opposed to the above results, for the EPHA3 locus, two ALS patients and 11 healthy controls with deletions were validated by TaqMan CNV assay. Here, HLA-B is linked to amyotrophic lateral sclerosis.