As opposed to the above loci, a 14 kb heterozygous deletion, spanning both the exonic and intronic parts of EPHA3 (chr3: 89,485,137–89,499,861) was found to be significantly protective for ALS, present in ∼10% of controls and only 2% of ALS patients (p = 0.0062) (Table 3) (Figure S1). The gene discussed is EPHA3; the disease is amyotrophic lateral sclerosis.