ANXA1 and brain neoplasm: To test this possibility, we intracranially injected U-87MG, U-87MG-control, U-87MG-RNAi, and U-87MG-RNAi-Anxa1 cells into nude mice and found that U-87MG, U-87MG-control, and U-87MG-RNAi-Anxa1 cells produced brain tumors in all of the injected mice, however, the U-87MG-RNAi cells produced brain tumor in only one injected mice (Fig. 5A).