Therefore, the aim of this study is to induce epilepsy in a macaque model with KA unilateral intra-hippocampal injection, which helps to evaluate the epileptogenesis, and observe the behavioral manifestations, alteration of magnetic resonance image (MRI) & magnetic resonance spectroscopy (MRS), histological pathology with glial fibrillary acid protein (GFAP) immunostaining of the macaque epilepsy model. Here, GFAP is linked to epilepsy.