Conflicting data has also been obtained using in vivo murine atherosclerosis models where one study showed that haematopoietic deficiency of miR-155 in LDLR−/− mice led to enhanced early atherosclerosis due to an increase in neutrophil migration [25], while another study more recently demonstrated that haematopoietic deficiency of miR-155 in ApoE−/− mice led to decreased atherosclerosis via inhibition of Bcl6 in macrophages [22]. This evidence concerns the gene LDLR and atherosclerosis.