Altogether, our data and data from the literature therefore supports the hypothesis that not only NHEJ-mediated repair but also replicative processes such as Break-Induced Replication (BIR), FoSTeS and/or MMBIR may account for genomic rearrangements in NB, as it has been suggested in other cancers from adult or children. Here, KCNJ11 is linked to neuroblastoma.