qPCR, luciferase reporter and Immunoblotting assays confirmed that lentivirus infection (10 MOI of Lv-MEK) resulted in elevated expression of MEK1 gene (Fig. 4a and 4c) and reactivated MAPK/ERK pathway in U-87 MG and GT-1# cells under OA treatment (Fig. 4b and 4c). The gene discussed is MAP2K1; the disease is lentivirus infection.