PTGDR2 and cancer: For example, we found that three genes (MAPK3, prostaglandin-endoperoxide synthase (PTGS)2, and G protein-coupled receptor (GPR)44) targeted by sulindac, a non-steroidal anti-inflammatory drug that is effective for the prevention of cancer [74], were dysregulated in the same directions in both UC and CRC in 13 CRC-related functions.