For this function, among the 12 DE genes dysregulated in both UC and CRC, eight genes (POLR2F, POLR2H, POLR2J, RPL15, RPL34, SUPT4H1, RDBP, and MDFIC) were dysregulated in opposite directions in the two diseases compared with normal controls. The gene discussed is RPL34; the disease is colorectal carcinoma.