For this function, among the 12 DE genes dysregulated in both UC and CRC, eight genes (POLR2F, POLR2H, POLR2J, RPL15, RPL34, SUPT4H1, RDBP, and MDFIC) were dysregulated in opposite directions in the two diseases compared with normal controls. This evidence concerns the gene POLR2J and colorectal carcinoma.