CD53 and neoplasm: All of the 22 UC-CRC inconsistent DE genes in the “humoral immunity”, including Igα, CD53 and CD27 which play key roles in regulating B-cell activation and immunoglobulin synthesis to mediated humoral immunity [52]–[54], were upregulated in UC but downregulated in CRC, in accordance with the observation that the immune system is hyperactive in UC [55], and that resting B cells can suppress T-cell-mediated anti-tumor immunity in tumors to promote tumor development [56].