Therefore, the purpose of this study was to evaluate the association of the Pro12Ala polymorphism of the PPARγ2 gene with plasma lipids, insulin resistance, and insulin secretion in a relatively large Chinese population and to examine whether the Pro12Ala polymorphism was associated with the risk of T2DM and obesity in this population. The gene discussed is PPARG; the disease is obesity due to melanocortin 4 receptor deficiency.